CovidPublicV1, Main, Exploration, bibRecord, 000052

The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2.

Identifieur interne : 000052 ( Main/Exploration ); précédent : 000051; suivant : 000053

The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2.

Auteurs : Pablo F. Garrido [Espagne] ; Martín Calvelo [Espagne] ; Alexandre Blanco-González [Espagne] ; Uxía Veleiro [Espagne] ; Fabián Suárez [Espagne] ; Daniel Conde [Espagne] ; Alfonso Cabez N [Espagne] ; Ángel Pi Eiro [Espagne] ; Rebeca Garcia-Fandino [Espagne]

Source :

International journal of pharmaceutics [ 1873-3476 ] ; 2020.

RBID : pubmed:32717282

Descripteurs français

KwdFr :
- Betacoronavirus (effets des médicaments et des substances chimiques), Betacoronavirus (métabolisme), Coagulation sanguine (effets des médicaments et des substances chimiques), Cyclodextrines (composition chimique), Cyclodextrines (pharmacologie), Excipients (composition chimique), Excipients (pharmacologie), Infections à coronavirus (prévention et contrôle), Infections à coronavirus (traitement médicamenteux), Nanostructures (MeSH), Pandémies (prévention et contrôle), Pneumopathie virale (prévention et contrôle), Pneumopathie virale (traitement médicamenteux), Stabilité de médicament (MeSH), Vaccins antiviraux (composition chimique), Vaccins antiviraux (pharmacologie), Vecteurs de médicaments (composition chimique), Vecteurs de médicaments (pharmacologie).
MESH :
- composition chimique : Cyclodextrines, Excipients, Vaccins antiviraux, Vecteurs de médicaments.
- effets des médicaments et des substances chimiques : Betacoronavirus, Coagulation sanguine.
- métabolisme : Betacoronavirus.
- pharmacologie : Cyclodextrines, Excipients, Vaccins antiviraux, Vecteurs de médicaments.
- prévention et contrôle : Infections à coronavirus, Pandémies, Pneumopathie virale.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- Nanostructures, Stabilité de médicament.

English descriptors

KwdEn :
- Betacoronavirus (drug effects), Betacoronavirus (metabolism), Blood Coagulation (drug effects), COVID-19 (MeSH), Coronavirus Infections (drug therapy), Coronavirus Infections (prevention & control), Cyclodextrins (chemistry), Cyclodextrins (pharmacology), Drug Carriers (chemistry), Drug Carriers (pharmacology), Drug Stability (MeSH), Excipients (chemistry), Excipients (pharmacology), Nanostructures (MeSH), Pandemics (prevention & control), Pneumonia, Viral (drug therapy), Pneumonia, Viral (prevention & control), SARS-CoV-2 (MeSH), Viral Vaccines (chemistry), Viral Vaccines (pharmacology).
MESH :
- chemical , chemistry : Cyclodextrins, Drug Carriers, Excipients, Viral Vaccines.
- drug effects : Betacoronavirus, Blood Coagulation.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- metabolism : Betacoronavirus.
- chemical , pharmacology : Cyclodextrins, Drug Carriers, Excipients, Viral Vaccines.
- prevention & control : Coronavirus Infections, Pandemics, Pneumonia, Viral.
- COVID-19, Drug Stability, Nanostructures, SARS-CoV-2.

Abstract

A handful of singular structures and laws can be observed in nature. They are not always evident but, once discovered, it seems obvious how to take advantage of them. In chemistry, the discovery of reproducible patterns stimulates the imagination to develop new functional materials and technological or medical applications. Two clear examples are helical structures at different levels in biological polymers as well as ring and spherical structures of different size and composition. Rings are intuitively observed as holes able to thread elongated structures. A large number of real and fictional stories have rings as inanimate protagonists. The design, development or just discovering of a special ring has often been taken as a symbol of power or success. Several examples are the Piscatory Ring wore by the Pope of the Catholic Church, the NBA Championship ring and the One Ring created by the Dark Lord Sauron in the epic story The Lord of the Rings. In this work, we reveal the power of another extremely powerful kind of rings to fight against the pandemic which is currently affecting the whole world. These rings are as small as ~1 nm of diameter and so versatile that they are able to participate in the attack of viruses, and specifically SARS-CoV-2, in a large range of different ways. This includes the encapsulation and transport of specific drugs, as adjuvants to stabilize proteins, vaccines or other molecules involved in the infection, as cholesterol trappers to destabilize the virus envelope, as carriers for RNA therapies, as direct antiviral drugs and even to rescue blood coagulation upon heparin treatment. "One ring to rule them all. One ring to find them. One ring to bring them all and in the darkness bind them." J. R. R. Tolkien.

DOI: 10.1016/j.ijpharm.2020.119689
PubMed: 32717282
PubMed Central: PMC7381410

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000166
to stream Main, to step Curation: 000166

Le document en format XML

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<term>Betacoronavirus (metabolism)</term>
<term>Blood Coagulation (drug effects)</term>
<term>COVID-19 (MeSH)</term>
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<term>Cyclodextrins (pharmacology)</term>
<term>Drug Carriers (chemistry)</term>
<term>Drug Carriers (pharmacology)</term>
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<term>Excipients (chemistry)</term>
<term>Excipients (pharmacology)</term>
<term>Nanostructures (MeSH)</term>
<term>Pandemics (prevention & control)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (prevention & control)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Viral Vaccines (chemistry)</term>
<term>Viral Vaccines (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Betacoronavirus (effets des médicaments et des substances chimiques)</term>
<term>Betacoronavirus (métabolisme)</term>
<term>Coagulation sanguine (effets des médicaments et des substances chimiques)</term>
<term>Cyclodextrines (composition chimique)</term>
<term>Cyclodextrines (pharmacologie)</term>
<term>Excipients (composition chimique)</term>
<term>Excipients (pharmacologie)</term>
<term>Infections à coronavirus (prévention et contrôle)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Nanostructures (MeSH)</term>
<term>Pandémies (prévention et contrôle)</term>
<term>Pneumopathie virale (prévention et contrôle)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
<term>Stabilité de médicament (MeSH)</term>
<term>Vaccins antiviraux (composition chimique)</term>
<term>Vaccins antiviraux (pharmacologie)</term>
<term>Vecteurs de médicaments (composition chimique)</term>
<term>Vecteurs de médicaments (pharmacologie)</term>
</keywords>
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<term>Drug Carriers</term>
<term>Excipients</term>
<term>Viral Vaccines</term>
</keywords>
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<term>Excipients</term>
<term>Vaccins antiviraux</term>
<term>Vecteurs de médicaments</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Betacoronavirus</term>
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</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Cyclodextrines</term>
<term>Excipients</term>
<term>Vaccins antiviraux</term>
<term>Vecteurs de médicaments</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cyclodextrins</term>
<term>Drug Carriers</term>
<term>Excipients</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pandemics</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pandémies</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>COVID-19</term>
<term>Drug Stability</term>
<term>Nanostructures</term>
<term>SARS-CoV-2</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Nanostructures</term>
<term>Stabilité de médicament</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">A handful of singular structures and laws can be observed in nature. They are not always evident but, once discovered, it seems obvious how to take advantage of them. In chemistry, the discovery of reproducible patterns stimulates the imagination to develop new functional materials and technological or medical applications. Two clear examples are helical structures at different levels in biological polymers as well as ring and spherical structures of different size and composition. Rings are intuitively observed as holes able to thread elongated structures. A large number of real and fictional stories have rings as inanimate protagonists. The design, development or just discovering of a special ring has often been taken as a symbol of power or success. Several examples are the Piscatory Ring wore by the Pope of the Catholic Church, the NBA Championship ring and the One Ring created by the Dark Lord Sauron in the epic story The Lord of the Rings. In this work, we reveal the power of another extremely powerful kind of rings to fight against the pandemic which is currently affecting the whole world. These rings are as small as ~1 nm of diameter and so versatile that they are able to participate in the attack of viruses, and specifically SARS-CoV-2, in a large range of different ways. This includes the encapsulation and transport of specific drugs, as adjuvants to stabilize proteins, vaccines or other molecules involved in the infection, as cholesterol trappers to destabilize the virus envelope, as carriers for RNA therapies, as direct antiviral drugs and even to rescue blood coagulation upon heparin treatment. "One ring to rule them all. One ring to find them. One ring to bring them all and in the darkness bind them." J. R. R. Tolkien.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32717282</PMID>
<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-3476</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>588</Volume>
<PubDate><Year>2020</Year>
<Month>Oct</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>International journal of pharmaceutics</Title>
<ISOAbbreviation>Int J Pharm</ISOAbbreviation>
</Journal>
<ArticleTitle>The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2.</ArticleTitle>
<Pagination><MedlinePgn>119689</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0378-5173(20)30673-6</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijpharm.2020.119689</ELocationID>
<Abstract><AbstractText>A handful of singular structures and laws can be observed in nature. They are not always evident but, once discovered, it seems obvious how to take advantage of them. In chemistry, the discovery of reproducible patterns stimulates the imagination to develop new functional materials and technological or medical applications. Two clear examples are helical structures at different levels in biological polymers as well as ring and spherical structures of different size and composition. Rings are intuitively observed as holes able to thread elongated structures. A large number of real and fictional stories have rings as inanimate protagonists. The design, development or just discovering of a special ring has often been taken as a symbol of power or success. Several examples are the Piscatory Ring wore by the Pope of the Catholic Church, the NBA Championship ring and the One Ring created by the Dark Lord Sauron in the epic story The Lord of the Rings. In this work, we reveal the power of another extremely powerful kind of rings to fight against the pandemic which is currently affecting the whole world. These rings are as small as ~1 nm of diameter and so versatile that they are able to participate in the attack of viruses, and specifically SARS-CoV-2, in a large range of different ways. This includes the encapsulation and transport of specific drugs, as adjuvants to stabilize proteins, vaccines or other molecules involved in the infection, as cholesterol trappers to destabilize the virus envelope, as carriers for RNA therapies, as direct antiviral drugs and even to rescue blood coagulation upon heparin treatment. "One ring to rule them all. One ring to find them. One ring to bring them all and in the darkness bind them." J. R. R. Tolkien.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Garrido</LastName>
<ForeName>Pablo F</ForeName>
<Initials>PF</Initials>
<AffiliationInfo><Affiliation>Departamento de Física Aplicada, Facultade de Física, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Calvelo</LastName>
<ForeName>Martín</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Departamento de Química Orgánica, Center for Research in Biological Chemistry and Molecular Materials, Universidade de Santiago de Compostela, Campus Vida s/n, E-15782 Santiago de Compostela, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blanco-González</LastName>
<ForeName>Alexandre</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Departamento de Química Orgánica, Center for Research in Biological Chemistry and Molecular Materials, Universidade de Santiago de Compostela, Campus Vida s/n, E-15782 Santiago de Compostela, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Veleiro</LastName>
<ForeName>Uxía</ForeName>
<Initials>U</Initials>
<AffiliationInfo><Affiliation>Departamento de Física Aplicada, Facultade de Física, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Suárez</LastName>
<ForeName>Fabián</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Departamento de Física Aplicada, Facultade de Física, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Conde</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Departamento de Química Orgánica, Center for Research in Biological Chemistry and Molecular Materials, Universidade de Santiago de Compostela, Campus Vida s/n, E-15782 Santiago de Compostela, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cabezón</LastName>
<ForeName>Alfonso</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Departamento de Química Orgánica, Center for Research in Biological Chemistry and Molecular Materials, Universidade de Santiago de Compostela, Campus Vida s/n, E-15782 Santiago de Compostela, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Piñeiro</LastName>
<ForeName>Ángel</ForeName>
<Initials>Á</Initials>
<AffiliationInfo><Affiliation>Departamento de Física Aplicada, Facultade de Física, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain. Electronic address: Angel.Pineiro@usc.es.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Garcia-Fandino</LastName>
<ForeName>Rebeca</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Departamento de Química Orgánica, Center for Research in Biological Chemistry and Molecular Materials, Universidade de Santiago de Compostela, Campus Vida s/n, E-15782 Santiago de Compostela, Spain. Electronic address: rebeca.garcia.fandino@usc.es.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>07</Month>
<Day>25</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Int J Pharm</MedlineTA>
<NlmUniqueID>7804127</NlmUniqueID>
<ISSNLinking>0378-5173</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D003505">Cyclodextrins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004337">Drug Carriers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005079">Excipients</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014765">Viral Vaccines</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001777" MajorTopicYN="N">Blood Coagulation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003505" MajorTopicYN="N">Cyclodextrins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004337" MajorTopicYN="N">Drug Carriers</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004355" MajorTopicYN="N">Drug Stability</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005079" MajorTopicYN="N">Excipients</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049329" MajorTopicYN="Y">Nanostructures</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014765" MajorTopicYN="N">Viral Vaccines</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Coronavirus</Keyword>
<Keyword MajorTopicYN="N">Cyclodextrins</Keyword>
<Keyword MajorTopicYN="N">Rings</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>05</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>07</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>7</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>10</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>7</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32717282</ArticleId>
<ArticleId IdType="pii">S0378-5173(20)30673-6</ArticleId>
<ArticleId IdType="doi">10.1016/j.ijpharm.2020.119689</ArticleId>
<ArticleId IdType="pmc">PMC7381410</ArticleId>
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</pubmed>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Galice</li>
</region>
<settlement><li>Santiago de Compostela</li>
</settlement>
<orgName><li>Université de Saint-Jacques-de-Compostelle</li>
</orgName>
</list>
<tree><country name="Espagne"><region name="Galice"><name sortKey="Garrido, Pablo F" sort="Garrido, Pablo F" uniqKey="Garrido P" first="Pablo F" last="Garrido">Pablo F. Garrido</name>
</region>
<name sortKey="Blanco Gonzalez, Alexandre" sort="Blanco Gonzalez, Alexandre" uniqKey="Blanco Gonzalez A" first="Alexandre" last="Blanco-González">Alexandre Blanco-González</name>
<name sortKey="Cabez N, Alfonso" sort="Cabez N, Alfonso" uniqKey="Cabez N A" first="Alfonso" last="Cabez N">Alfonso Cabez N</name>
<name sortKey="Calvelo, Martin" sort="Calvelo, Martin" uniqKey="Calvelo M" first="Martín" last="Calvelo">Martín Calvelo</name>
<name sortKey="Conde, Daniel" sort="Conde, Daniel" uniqKey="Conde D" first="Daniel" last="Conde">Daniel Conde</name>
<name sortKey="Garcia Fandino, Rebeca" sort="Garcia Fandino, Rebeca" uniqKey="Garcia Fandino R" first="Rebeca" last="Garcia-Fandino">Rebeca Garcia-Fandino</name>
<name sortKey="Pi Eiro, Angel" sort="Pi Eiro, Angel" uniqKey="Pi Eiro A" first="Ángel" last="Pi Eiro">Ángel Pi Eiro</name>
<name sortKey="Suarez, Fabian" sort="Suarez, Fabian" uniqKey="Suarez F" first="Fabián" last="Suárez">Fabián Suárez</name>
<name sortKey="Veleiro, Uxia" sort="Veleiro, Uxia" uniqKey="Veleiro U" first="Uxía" last="Veleiro">Uxía Veleiro</name>
</country>
</tree>
</affiliations>
</record>

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The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2.

The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2.

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